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In the only study we found that required histologic confirmation of alcoholic hepatitis in all patients, prednisolone was associated with a short-term reduction in mortality, but this benefit was not apparent after 2 years.
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Indirect immunofluorescence microscopy is used as a screening test for serum autoantibodies in autoimmune blistering skin diseases.
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While prednisolone is often substituted for dexamethasone when the latter is unavailable, the efficacy of prednisolone has never been directly compared with dexamethasone.
Since infection plays such an important role in the outcome of alcoholic hepatitis, it is worth noting that in a trial published in 2011, the addition of N-acetylcysteine to prednisolone was associated with a reduced rate of infection.
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Adverse events included the expected range of minor symptoms associated with the drugs used ( Table 4 Adverse Events.
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Symptoms disappeared on the same day of onset without further treatment.
In diseases caused by microorganisms, infection may be masked, activated, or enhanced by corticosteroids.
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Of note, direct inhibition of autoantibody production was only seen at the higher dose of MMF, whereas qualitative changes with a reduction in total and antigen-specific IgG2a were seen at the lower dose of MMF, suggesting that this might be one of the mechanisms resulting in disease amelioration.
Betamethasone; cortisone; dexamethasone; hydrocortisone; methylprednisolone; prednisolone; prednisone; and triamcinolone are indicated for treatment of severe cases not controlled by antimyasthenic agents alone.
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